By H. Joachim Deeg M.D., Hans-Georg Klingemann M.D., Ph.D., Gordon L. Phillips M.D., Gary Van Zant Ph.D. (auth.)

ISBN-10: 3642182488

ISBN-13: 9783642182488

ISBN-10: 3642621228

ISBN-13: 9783642621222

This publication offers an advent to marrow and peripheral blood stem mobile transplantation (including twine blood transplants), emphasizing the foundations of this speedily evolving zone. a short ancient viewpoint is given and the newest advancements are mentioned. specific cognizance is given to the explanation and symptoms for transplantation, the choice of donors and resource of stem cells, and the separation, growth and manipulation of stem cells. crucial elements of histocompatibility, preparative regimens utilized in stem mobilephone transplantation, using hematopoietic development elements and cytokines, the pathophysiology of the graft-versus-host response, and the administration of problems are handled. This ebook should still give you the practising internist, pediatrician, hematologist, and oncologist in addition to different physicians in education or in perform, physicians' assistants, nurses, and scholars with the knowledge essential to comprehend the ideas of stem mobile transplantation and to incorporate transplantation within the remedy making plans quickly after a analysis has been tested. The textual content must also be necessary to the medical professional who resumes the sufferers' care after they go back from the transplant center.

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Additional resources for A Guide to Blood and Marrow Transplantation

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See Table 5). Not all these points are discussed; the following deserve special emphasis. Preparation for Stem Cell Transplantation 39 Table 5. Preparation of the patient for stem cell transplantation A. Complete medical history of both patient and donor (if applicable), including: 1. Unequivocal documentation of diagnosis 2. , doxorubicin) agents, as well as current level of response obtained 3. Specific disease or treatment-related problems 4. Co-morbid medical problems that might complicate or preclude transplantation (or donation) 5.

For marrow harvests this number was (and is) on the order of 2x lOB/kg body weight of the recipient for autografts. An increase by a factor of 2-4 in cell number is usually deemed advisable for allografts. Any in vitro measure of progenitor numbers determined by colony formation requires about two weeks, and, thus, in allografting this indication of graft quality is typically obtained retrospectively, after the recipient has been infused. Since autografts are often stored frozen for at least two weeks before infusion, while the patient is being conditioned, there is time to obtain a prospective assessment of graft quality, and to take corrective measures if needed.

Depending on these discussions, consultation with a social worker or other professional should be considered. It is beyond the scope of this chapter to address the complicated area denoted "quality of life" after transplantation. Nonetheless, this is a vital issue. Full discussion is critical, emphasizing that while recovery may be anticipated, it may be incomplete, especially in the allogeneic setting with the possibility of chronicGVHD. Moreover, less obvious problems related to family tensions and "embarrassing" topics such as diminished sexual performance following transplantation should be aired.

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A Guide to Blood and Marrow Transplantation by H. Joachim Deeg M.D., Hans-Georg Klingemann M.D., Ph.D., Gordon L. Phillips M.D., Gary Van Zant Ph.D. (auth.)


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