By Drew Provan

ISBN-10: 0727916769

ISBN-13: 9780727916761

This moment variation of the ABC of medical Haematology is a finished and useful advisor to this vast ranging speciality, protecting the haematological features of such components as pathology, molecular technological know-how, melanoma, and normal drugs. this can be a brief quantity along with chapters on all parts of haematology written by way of those that take care of those ailments each day. The publication presents descriptions of those illnesses and describes the pathways fascinated with prognosis and remedy. complete color is used all through this seriously illustrated ebook, utilizing scientific fabric and textual content bins to emphasize key issues. we now have additionally attempted to maintain jargon to a minimal in order that the textual content doesn't require large earlier wisdom.

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It acts by specifically inhibiting the enhanced protein tyrosine kinase activity of the Bcr–Abl oncoprotein and kills leukaemia cells by inducing apoptosis. e. 600 or 800 mg daily) may prove superior. It induces complete haematological remission in > 95% of previously untreated patients and 70–80% of these will achieve complete cytogenetic remission. The best way of monitoring the patient’s response to imatinib is by regular assay of Bcr–Abl transcript numbers in the peripheral blood using the real-time quantitative RT–PCR technology.

7 Features of a poor prognosis in myelofibrosis • • • • • • Haemoglobin <·10 g/dL White cell count <·4 or >·30·×·109/L Bone marrow chromosomal abnormalities Advanced patient age Raised number of CD34-positive cells in the peripheral blood Presence of JAK2 V617F mutation Bone marrow transplantation from a matched sibling or unrelated donor should be offered to young patients with poor prognostic features. This is the only curative treatment modality for myelofibrosis, but, in view of its toxicity, it cannot be performed in the majority of patients with this disorder, who are >·50·years old at diagnosis.

Chest radiography A mediastinal mass may be present, particularly in T-cell ALL. Lumbar puncture in patients with ALL The presence of leukaemia in the central nervous system (CNS) should be suspected if there are symptoms of headache, visual disturbance or abnormalities such as blurred disc margins or retinal haemorrhage on fundoscopy. It is common at diagnosis and relapse in ALL but only rarely occurs in AML. Principles of treatment Acute leukaemia is a life-threatening, but potentially curable, disease and should be managed by a specialist multidisciplinary team.

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ABC of Clinical Haematology (ABC Series) by Drew Provan

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