By Pinuccia Valagussa (auth.), Monica Castiglione, Martine J. Piccart (eds.)

ISBN-10: 0387751149

ISBN-13: 9780387751146

ISBN-10: 0387751157

ISBN-13: 9780387751153

Adjuvant remedy is run sooner than or as persist with as much as surgeries for breast melanoma. confirmed good fortune in utilizing scientific treatments taking into account breast maintaining systems or lowering possibility of incidence. even supposing there was a lot growth in the direction of a treatment, together with the creation of recent distinct remedies, metastasizing melanoma is still hugely incurable.

"The adjuvant therapy of breast melanoma has develop into ordinary of care. A spectrum of biologic and prognostic components are thought of earlier than a healing method is carried out. during this textual content prime investigators within the box talk about present administration and demanding investigative issues."

Steven T. Rosen, M.D.
Series Editor

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Additional info for Adjuvant Therapy for Breast Cancer

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Perspectives Undoubtedly, tumor profiling and nano-technology are powerful means to achieve revolutionary progress in the clinical management of breast cancer. For example, tumor profiling has led to the understanding that estrogen receptor positive and negative breast tumors are different biological diseases which can be further sub-grouped with respect to prognosis and treatment response [35]. Ideally, profiling of an individual tumor by one or a combination of the ‘‘omics’’ approaches will allow the administration of an effective tailored treatment regimen.

Moreover, analysis of the metabolome in fine needle ovarian biopsies by mass spectrometry has allowed the distinction between borderline tumors and cancer [27]. As mentioned above, metabolite analysis can also be restricted to metabolites specific for defined signalling pathways (metabolite target analysis). This approach may have an important potential in the assessment of breast cancer risk and breast cancer diagnosis. It is generally accepted that the exposure to estrogen is a main risk factor for breast cancer and that oxidative metabolites of estrogen may be causally involved in the development of the disease.

2007;Mar 17 [ahead of print]. 75. Veitia R, Bissery MC, Martinez C, et al. Tau expression in model adenocarcinomas correlates with docetaxel sensitivity in tumor-bearing mice. Br J Cancer. 1998;78:871–7. 76. Rouzier R, Rajan R, Wagner P, et al. Microtubule-associated protein tau: A marker of paclitaxel sensitivity in breast cancer. Proc Natl Acad Sci U S A. 2005;102:8315–20. 77. Chang JC, Wooten EC, Tsimelzon A, et al. Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer.

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Adjuvant Therapy for Breast Cancer by Pinuccia Valagussa (auth.), Monica Castiglione, Martine J. Piccart (eds.)


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