By M. H. N. Tattersall (auth.), Professor Dr. Hans-Jörg Senn, Priv.-Doz. Dr. Aron Goldhirsch, Dr. Richard D. Gelber, Dr. Bruno Osterwalder (eds.)

ISBN-10: 3642833373

ISBN-13: 9783642833373

ISBN-10: 364283339X

ISBN-13: 9783642833397

The final "consumer" of the knowledge offered at meetings at the basic therapy of operable breast melanoma is the sufferer, and whilst, as during this ailment, the advantages of treatment are particularly mod­ est, the provision and interpretation of the information from trials be­ comes a topic of fundamental significance. the consequences of current deal with­ ment are in reality such that extra sufferers relapse regardless of treatment than are envisioned to profit from it. it's, for that reason, tremendous dif­ ficult for the doctor to suggest unequivocally one specific adjuvant remedy modality for the gigantic inhabitants of ladies with breast melanoma. the translation of effects from medical research-oriented professional­ grams is consistently utilized, besides the fact that, within the therapy of breast melanoma sufferers outdoors of medical trials. From offered or submit­ ed info, many physicians extrapolate symptoms for using a given remedy routine for his or her sufferers, perceiving it because the "best on hand remedy. " it truly is crucial that the "best to be had treatment" be chosen separately for every sufferer. even though, contemplating the modest influence of therapy upon end result, it really is primary that those that give you the info - those who find themselves interested by either pa­ tient care and medical learn - make it recognized that the easiest cur­ hire remedy for the inhabitants of breast melanoma sufferers is avail­ capable in the framework of medical trials. during this method not just present-day sufferers but additionally destiny ones will derive the best benefit.

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Springer, Berlin Heidelberg New York Tokyo pp 85-94 (Recent results in cancer research, vol 103) Ragaz J, Band PR, Goldie JH (eds) (1986) Preoperative (neoadjuvant) chemotherapy. Springer, Berlin Heidelberg New York (Recent results in cancer research, vol 103) Ragaz J, Manji M, Olivotto I et al. (1987 a) Role of mastectomy in preoperative (neoadjuvant) combined modality therapy of locally advanced breast cancer. Proc Am Soc Clin Onco16:55 Ragaz J, Coldman A, Salinas F, Worth A, Manji M, Goldie J (1987b) Neoadjuvant chemotherapy for breast cancer.

1978), followed by osteosarcoma (Sampat et al. 1987), head and neck tumors (Frei et al. 1986) and locally advanced breast cancer (Balawajder et al. 1983; Hortobagyi et al. 1987; Lippman et al. 1986b; Morris et al. 1978; Ragaz et al. 1987). More recently completed studies documenting the safety of more dose-intensive preoperative chemotherapy with anthracycline (Hortobagyi et al. 1987; Lippman et al. 1986b; Ragaz et al. 1987 a) revived previous interest, resulting at present in a quest for a more organized approach towards neoadjuvant therapy (Jacquillat et al.

L-\_~--e-_e r T T4 (482%) 11 8 4 5 6 7 [,0, o 2 3 [, Years Fig. 2. Jacquillat et al. Table 4. Influence of tamoxifen on tumor regression Regression> 75'Vo Group (0/0) (n) I, II III, IV Total TAM+ TAMTAM + TAM- 66/ 19/ 54/ 19/ 93 43 79 37 1371205 71 44 68 51 67 TAM +, tamoxifen therapy ; TAM -, no tamoxifen. 88% for those whose tumor regression was over 75%. , 54% for slow responders and 64% for good responders). 2. As shown in Table 4, tumor regression of over 75% was more frequent in patients who received tamoxifen (Nolvadex) in addition to chemotherapy, especially in groups I and I l.

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Adjuvant Therapy of Primary Breast Cancer by M. H. N. Tattersall (auth.), Professor Dr. Hans-Jörg Senn, Priv.-Doz. Dr. Aron Goldhirsch, Dr. Richard D. Gelber, Dr. Bruno Osterwalder (eds.)


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