By Alfred G. Knudson Jr. (auth.), Harry Harris, Kurt Hirschhorn (eds.)
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Epigenetics can almost certainly revolutionize our realizing of the constitution and behaviour of organic existence on the earth. It explains why mapping an organism's genetic code isn't really sufficient to figure out the way it develops or acts and indicates how nurture combines with nature to engineer organic variety. Surveying the twenty-year historical past of the sphere whereas additionally highlighting its newest findings and concepts, this quantity presents a effectively comprehensible creation to the principles of epigenetics.
Nessa Carey, a number one epigenetics researcher, connects the field's arguments to such assorted phenomena as how ants and queen bees regulate their colonies; why tortoiseshell cats are constantly girl; why a few vegetation want chilly climate sooner than they could flower; and the way bodies age and strengthen sickness. achieving past biology, epigenetics now informs paintings on drug dependancy, the long term results of famine, and the actual and mental results of youth trauma. Carey concludes with a dialogue of the long run instructions for this examine and its skill to enhance human future health and well-being.
In der nun neunten Auflage wendet sich dieser Klassiker an Studierende der Chemie im Grundstudium oder einem Bachelor-Studiengang sowie an Studierende mit Chemie als Nebenfach. Der ursprünglich aus den united states kommende, glänzend ins deutsche übersetzte textual content ist einfach und verständlich geschrieben, ergänzt durch zahlreiche Abbildungen, Grafiken und Übungsaufgaben.
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Additional info for Advances in Human Genetics 8
These pedigrees are consistent with dominant inheritance. Some families in this group show a high association of this cancer with obesity, hypertension, and diabetes mellitus. 22,184 A stigmatizing condition associated with endometrial cancer is the Stein-Leventhal syndrom~, an endocrine dysplasia characterized by amenorrhea, sterility, hirsutism, obesity, and ovarian cystS. 133 The syndrome may be dominantly inherited. 51 On the other hand, carcinoma of the cervix uteri is rarely, if ever, inherited, although Rotkin 251 has found an excess of skin cancer among relatives of cervical cancer patients and has suggested a predisposition to squamous epithelial neoplasia.
Germinal and Teratoid Tumors Included in the category of germinal and teratoid tumors are seminoma, dysgerminoma, choriocarcinoma, embryonal carcinoma, ter- Chapter 1: Genetics and Etiology of Human Cancer 37 atoma, dermoid cyst, and teratocarcinoma. Some tumors demonstrate more than one component, and malignant tumors may arise from a partially differentiated sector of a teratoma. The sites at which the tumors occur are varied, the most common being the gonads and the sacrococcygeal area, with the exception of the gestational form of choriocarcinoma.
161 ,206,283 The association of pulmonary fibrosis and lung cancer has also been noted in other pedigrees. 24,63 In reviewing the whole problem of genetic predisposition to lung cancer, Mulvihill218 has raised the possibility that pulmonary fibrosis and lung cancer may be associated via a genetic predisposition to scleroderma. This association could also be mediated via a heritable immunological abnormality, especially in view of the occurrence of two cases of lung cancer in a pedigree afflicted with lymphoproliferative disorders.
Advances in Human Genetics 8 by Alfred G. Knudson Jr. (auth.), Harry Harris, Kurt Hirschhorn (eds.)