By Robin Holliday
For hundreds of years humans were wondered through the inevitability of human getting older. for many of the second one 1/2 the 20 th century getting older remained a secret, or an unsolved organic challenge. on the finish of the 20 th century a striking clinical discovery emerged. It was once now not a unmarried discovery within the traditional experience, since it was once according to a sequence of vital interconnected insights over relatively a protracted time period. those insights made it attainable for the first actual time to appreciate the organic purposes for getting older in animals and guy. it may well already be stated, even though, that the various observations and insights that designate getting older usually are not authorised as demonstrated wisdom for a very long time. the sphere continues to be jam-packed with scientists, and non-scientists, who're simply satisfied to move on speculating concerning the 'mystery' of getting older. the purpose of this booklet is to dispel lack of know-how through explaining in non-technical language what are the explanations for getting older and the parable of over the top prolongation of existence.
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Additional resources for Ageing : the paradox of life
Cholesterol-rich lesions known as atheromatous plaques appear and gradually increase in size. These can eventually block blood flow, which in turn can lead to a failure of the normal oxygen supply to the heart, with a consequent heart attack, or lethal heart failure. The formation of blood clots or the detachment of plaques from the arterial wall can impede the blood supply to the brain. and cause a stroke. The arterial walls are elastic in young individuals, but with time the cross-linking of collagen and elastin reduces elasticity and thickening of the walls may also occur (hardening of the arteries).
A good example of this is the increase in blood pressure that occurs during ageing. This may be largely due to the loss of elasticity of the walls of major arteries (hardening of the arteries). High blood pressure has deleterious effects, and may in the end lead to kidney failure, and the requirement of a dialysis machine, or a kidney transplant. High blood pressure can also result in the rupture of a brain artery, and a slight or a severe stroke may result. It can also have serious effects on the retina of the eye.
Alternatively, the correct folding of the amino acids chain may change to produce what is known as a denatured, or partially denatured, molecule. Most amino acids can exist in two forms, one left handed (L) and one right handed (D). In all living organisms only the L forms are found in proteins. (This is a quirk of nature to do with the origin of life, and its subsequent evolution). However, there is a given low probability that an L amino acid will change spontaneously into a D amino acid. This is known to occur in long lived proteins in teeth, and also in the lens, but at a very slow rate.
Ageing : the paradox of life by Robin Holliday