By Shaker A. Mousa
1This selection of evaluation articles highlights the most recent improvement of antithrombotics and gives confirmed experimental tools for the extra improvement of latest and more suitable anticoagulants. one of the state-of-the-art advancements reviewed are the radical utilization of low molecular weight heparins, such antithrombin brokers because the hirudin, and such antiplatelet medicinal drugs because the GPIIb/IIIa inhibitors and ADP receptor antagonists. extra recommendations mentioned comprise aspirin and clopidogrel, the increased use of polytherapeutic ways, antiproteases (factors IIa, Xa, and VIIa), tissue issue concentrating on, platelet receptor focusing on, and antithrombin III modulation.
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Additional resources for Anticoagulants, Antiplatelets, and Thrombolytics (Methods in Molecular Medicine)
Tinzaparin is a potent anticoagulant as compared to other known LMWH (6). Tinzaparin is more effective than UFH as treatment for DVT, is effective in the treatment of pulmonary embolism (PE), and the prevention of DVT in abdominal surgery patients, and is superior to warfarin as thromboembolism prophylaxis in subjects who are undergoing orthopedic joint (hip or knee) replacement surgery (7–10). It is also an effective anticoagulant for hemodialysis extracorporeal circuits (11). Tinzaparin has been marketed for more than 10 yr in Europe, 6 yr in Canada, and more recently, has been FDA-approved in the United States and worldwide under the trade name Innohep (Leo Pharmaceutical Products).
Konstantopoulos, K. and Mousa, S. A. (2001) Antiplatelet therapies: platelet GPIIb/IIIa antagonists and beyond. Current Opinion in Investigational Drugs 2, 1086–1092. 9. Mousa, S. A. (1999) Antiplatelet therapies: recent advances in the development of platelet GPIIb/IIIa antagonists, in Current Interventional Cardiology Reports, Vol. 1. (Holmes, D. ), Current Science, Philadelphia, PA, pp. 243–252. 10. , et al. (1998) Induction of fibrinogen binding and platelet aggregation as a potential intrinsic property of various glycoprotein IIb/IIIa inhibitors.
8. CH03,21-34,14pgs 9/5/03 11:01 AM Page 28 28 McCarty et al. 2. Homogenize for 3 h. 3. Centrifuge the homogenate at 200g for 10 min, collect supernatant, and measure collagen concentration by a modified Lowry analysis (23). 4. 7 × 23), and place in a humid environment at 37°C for 45 min. 5. Rinse excess collagen with 10 mL of D-PBS maintained at 37°C before assembly into the flow chamber (see Note 5). 2. Platelet Perfusion Studies 1. Add the fluorescent dye quinacrine dihydrochloride to anticoagulated whole blood samples at a final concentration of 10 µM immediately after blood collection.
Anticoagulants, Antiplatelets, and Thrombolytics (Methods in Molecular Medicine) by Shaker A. Mousa